Examination of Iron Metabolism Markers in Patients with Malignant and Benign Processes of Ovaries and Uterus

Aim of the study to determine iron metabolism markers in with benign and malignant processes of ovaries and uterus. Study object: blood serum of 50 patients with benign and malignant processes of ovaries and uterus. Methods: clinical, morphological, immunoenzyme, immunochemiluminescent, immunoturbidimetric. Results: in the group of patients with malignant processes there were more patients with alterations of blood serum iron (46,9%), ferritin (28,2%), and transferrin (59%) concentration.) than in the group with benign processes, 22.3%, 11.2%, and 0%, respectively. In the blood serum of 45% of ovarian cancer (OC) patients decrease of iron concentration was determined, in 25% of patients – ferritin (FER) concentration increase was seen. It was demonstrated that number of patients with decreased transferrin (TRFER) saturation with iron is seen more often in patients with ovarian cancer of III-IV stage, than in I stage, in 95 and 75% of patients, respectively. Individual variations of all iron metabolism markers in patients with malignant and benign processes of ovaries and uterus were determined. Conclusion: alterations of iron metabolism markers indicate its more often disorders in patients with malignant processes, and they may be used in practical oncogynecology as potential markers of iron metabolism disturbances and its monitoring in the process of antitumor therapy of patients with ovarian and uterine cancer.